Right before using this medication, Ladies of childbearing age should really talk to their medical doctor(s) with regards to the risks and Advantages. Explain to your doctor When you are pregnant or Consider you may well be pregnant. In the course of pregnancy, this medication will not be advisable. It could slightly enhance the hazard of delivery defects if made use of through the initially two months of pregnancy. Also, using it for some time or in higher doses near the envisioned delivery date might harm the unborn baby.
Before getting this medication, explain to your doctor or pharmacist If you're allergic to promethazine or to dextromethorphan; or to another phenothiazines (like prochlorperazine); or if you have almost every other allergies.
Critical hypotension usually responds to the administration of norepinephrine or phenylephrine. EPINEPHRINE Really should not be Employed, because its use inside a patient with partial adrenergic blockade may further more lessen the blood pressure.
Dosage of codeine Shouldn't be Elevated if cough fails to reply; an unresponsive cough should be reevaluated in 5 days or sooner for achievable fundamental pathology, for example foreign entire body or lower respiratory tract ailment.
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Parenteral drug abuse is usually connected with transmission of infectious ailments like hepatitis and HIV.
, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer including rifampin, carbamazepine, and phenytoin, could bring about a rise in codeine plasma concentrations with subsequently higher metabolism by cytochrome P450 2D6, leading to better morphine stages, which could improve or extend adverse reactions and will lead to perhaps fatal respiratory depression.
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CONDITIONS OF USE: The data In this particular database is meant to complement, not substitute for, the expertise and judgment of Health care specialists. The information just isn't intended to address all possible makes use of, Instructions, precautions, drug interactions or adverse results, nor ought to it's construed to point that usage of a specific drug is Safe and sound, proper or productive for you or anybody else.
Right assessment on the individual, good prescribing procedures, periodic re-evaluation of therapy, and good dispensing and storage are proper steps that support to limit abuse of opioid drugs.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, necessitating careful consideration of the consequences around the guardian drug, codeine, as well as Energetic metabolite, morphine.
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When used for an prolonged time, this medication may well not perform also and may call for unique dosing. Talk to your health care provider if this medication stops working well.
If you do not Have a very drug take-back spot near you, flush any unused narcotic medicine down the rest room. Examine your neighborhood drug retailer and clinics for just take-back areas. You can also Promethazine codeine syrup Test the DEA Web-site for spots. Here is the link on the FDA safe disposal of medicines website: